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The Monastery of San Marco was founded in the early twelfth century. In 1437, the monastery was given to the Dominican order. The reconstruction of the entire ensemble was carried out under the architect Michelozzo, who built the cells and cloisters, later decorated by a Florentine artist. decorated by the Florentine painter and Dominican friar Fra Beato Angelico. with frescoes of religious themes. Savonarola lived here in one of the cells, and the Greek Michael Trivonarola. Greek Michael Trivolis, who later came to Moscow and became famous as Maxim the Greek. Maxim the Greek. In 1866, the monastery was closed and now houses the Museum of the Museum of the Monastery of San Marco.

Most of the frescoes in St Antonio's Cloister are by Bernardino Poccetti, depicting scenes from the life of St Anthony. The corner panels are painted by Fra Angelico. В in the hall of the Ospizio (pilgrims' shelter) is an altarpiece by Fra Angelico. "Deposition from the Cross." The vaulted Capitulum Hall is decorated with frescoes by Fra Angelico "Crucifixion" and "St Dominic". In the small refectory, one wall is completely covered by a fresco by Ghirlandaio. by Ghirlandaio's fresco of the Last Supper. Here is also the famous "Annunciation" by Fra Angelico.