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How to Travel from

La Serena to Cusco

by Train, Route or Car

La Serena
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Cusco
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La Serena
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Cusco
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Schedule

La Serena, Chile → Cusco, Peru

All
26 Feb 2026
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Four ways to Travel from La Serena to Cusco

Composite routes from La Serena to Cusco

Cheapest
Other

Transport providers

Airlines

Sky Airline

Website:
skyairline.com/
Plane from La Florida Airport to Alejandro
Ave. Duration:
10h 37m
Frequency:
Thursday, Friday, and Sunday
Estimated price:
$114.50–$368.96

LATAM Chile

Website:
latam.com/
Plane from La Florida Airport to Alejandro
Ave. Duration:
5h 50m
Frequency:
Wednesday, Thursday, and Sunday
Estimated price:
$127.23–$381.68

Bus operators

Pullman Bus

Phone:
+56 600 600 0018
Website:
pullmanbus.cl
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
22h 40m
Frequency:
Twice daily
Estimated price:
$53.43–$85.93

Buses Norte Grande

Phone:
+56 58 222 8603
Website:
recorrido.cl/es/bus/buses-norte-grande-pasajes
Bus from Terminal Internacional to Tacna
Ave. Duration:
1h
Frequency:
Every 30 minutes
Estimated price:
$4.75

Peru Runa Travels

Phone:
+56 975 370 786
Website:
perurunatravel.com/en/
Bus from Terminal Internacional to Tacna
Ave. Duration:
1h
Frequency:
Every 30 minutes
Estimated price:
$4.75

Flores Hermanos

Phone:
+51 1 4800725
Website:
floreshnos.pe/
Bus from Tacna to Arequipa
Ave. Duration:
6h
Frequency:
Every 4 hours
Estimated price:
$21.63–$27.99

Expreso Turismo San Martin Nobleza

Phone:
+51 051 602 943
Website:
facebook.com/SanMartinNobleza/
Bus from Tacna Bus Station to Cusco
Ave. Duration:
15h 30m
Frequency:
Twice daily
Estimated price:
$24.17–$33.08
Bus from Tacna to Puno
Ave. Duration:
6h 30m
Frequency:
Once daily
Estimated price:
$12.09–$16.54

Turbus

Phone:
+56 22 822 7500
Website:
turbus.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
17h 5m
Frequency:
Every 4 hours
Estimated price:
$34.35–$127.23

Pullman San Andrés

Website:
pullmansanandres.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
23h 20m
Frequency:
5 times a day
Estimated price:
$39.44–$67.67

Ramos Cholele

Phone:
+56 57 226 9210
Website:
busesramoscholele.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
23h 20m
Frequency:
Twice daily
Estimated price:
$38.17–$58.52

Pluss Chile

Phone:
+56 22 3813 550
Website:
plusschile.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
22h 35m
Frequency:
3 times a day
Estimated price:
$35.62–$58.52

Kenny Bus

Phone:
+56 22 570 8687
Website:
kennybus.cl/
Bus from Iquique to Terminal
Ave. Duration:
4h 20m
Frequency:
5 times a day
Estimated price:
$16.54–$24.17

Pullman Cuevas

Phone:
+56 58 2241090
Website:
kupos.cl/es/pasajes/bus/buses-pullman-cuevas
Bus from Iquique to Terminal
Ave. Duration:
4h
Frequency:
Once daily
Estimated price:
$16.59

Andoriña Tours

Phone:
+51 993 585 217
Bus from Arequipa to Cusco
Ave. Duration:
5h 30m
Frequency:
Once daily
Estimated price:
$21.31

Hallpa

Website:
hallpa.pe/
Bus from Tacna to Arequipa
Ave. Duration:
6h
Frequency:
Twice daily
Estimated price:
$18.27

Train operators

PeruRail

Phone:
+51 1625 4848
Website:
perurail.com/es/
Train from Puno to Cusco
Ave. Duration:
10h 20m
Frequency:
4 times a week
Estimated price:
$267.17–$4,452.91

Questions and Answers

What is the cheapest way to get from La Serena to Cusco?

The cheapest way to get from La Serena to Cusco is to bus which costs $54.35 - $173.91 and takes 39h 37m.

What is the fastest way to get from La Serena to Cusco?

The fastest way to get from La Serena to Cusco is to fly which takes 6h 37m and costs $108.70 - $358.70 .

Is there a direct bus between La Serena and Cusco?

No, there is no direct bus from La Serena to Cusco. However, there are services departing from Terminal de Buses La Serena and arriving at Cusco via Iquique, Terminal Internacional, Tacna and Arequipa. The journey, including transfers, takes approximately 37h 13m.

How far is it from La Serena to Cusco?

The distance between La Serena and Cusco is 1833 km. The road distance is 2406.5 km.

How do I travel from La Serena to Cusco without a car?

The best way to get from La Serena to Cusco without a car is to bus via Arequipa which takes 37h 13m and costs $81.52 - $173.91 .

How long does it take to get from La Serena to Cusco?

It takes approximately 6h 37m to get from La Serena to Cusco, including transfers.

Where do I catch the La Serena to Cusco bus from?

La Serena to Cusco bus services, operated by Turbus, depart from Terminal de Buses La Serena station.

Bus or fly from La Serena to Cusco?

The best way to get from La Serena to Cusco is to fly which takes 6h 37m and costs $108.70 - $358.70 . Alternatively, you can bus via Arequipa, which costs $81.52 - $173.91 and takes 37h 13m.

Where does the La Serena to Cusco bus arrive?

La Serena to Cusco bus services, operated by Turbus, arrive at Terminal Esmeralda - Turbus station.

What is the time difference between La Serena and Cusco?

Cusco is 2h behind La Serena. It is currently 06:28 in La Serena and 04:28 in Cusco.

Can I drive from La Serena to Cusco?

Yes, the driving distance between La Serena to Cusco is 2407 km. It takes approximately 31h to drive from La Serena to Cusco.

Where can I stay near Cusco?

There are 1236+ hotels available in Cusco. Prices start at $26.65 per night.
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