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How to Travel from

Santiago to Cusco

by Plane, Route or Car

Santiago
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Cusco
Transport search to Cusco
Santiago
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Cusco
Building a composite car route
Cheapest
Best Offer!
Car
36 h 46 min
2813 km.
from $154
Composite Route Car Only
Schedule

Santiago, Chile → Cusco, Peru

All
04 Jul 2026
July 2026
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All days
05 Jul, Sun
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Cheapest and Fastest Ways to Travel from Santiago to Cusco

Composite routes from Santiago to Cusco

Cheapest
Fastest
Other

Transport providers

JetSMART
Website
Sky Airline
Website
LATAM Chile
Website
JetSMART
Website
6h 53m
Monday, Wednesday, Saturday, and Sunday
$141.30–$423.91
Sky Airline
Website
7h 22m
Every day
$119.57–$423.91
LATAM Chile
Website
3h 35m
Every day
$141.30–$445.65
Transporte Internacional Litoral
Website
Autotransportes SAMA
Website
Trans Salvador
Website
Nuevo Continente Internacional
Website
Pullman Bus
Website
Buses Norte Grande
Website
Peru Runa Travels
Website
Flores Hermanos
Website
Predilecto Tours
Website
Expreso Turismo San Martin Nobleza
Website
Turbus
Website
Pullman San Andrés
Website
Ramos Cholele
Website
Pluss Chile
Website
Covalle Bus
Buses Horizonte
Website
Jet Nort Super Class
Website
Andoriña Tours
Hallpa
Website
Transporte Internacional Litoral
Website
15h
Once daily
$40.23
+591 2 228 1920
+591 2 228 1920
Call Contact via email
Autotransportes SAMA
Website
5h 6m
Once daily
$13.04–$22.83
+591 466-60443
+591 466-60443
Call Contact via email
Trans Salvador
Website
16h
Every 4 hours
$20.65–$44.57
+56 58 222 8547
+56 58 222 8547
Call Contact via email
Nuevo Continente Internacional
Website
16h
Twice daily
$173.91–$250.00
+591 22283843
+591 22283843
Call Contact via email
Pullman Bus
Website
29h
Twice daily
$54.35–$77.03
+56 600 600 0018
+56 600 600 0018
Call Contact via email
Buses Norte Grande
Website
1h
Every 30 minutes
$4.18
+56 58 222 8603
+56 58 222 8603
Call Contact via email
Peru Runa Travels
Website
1h
Every 30 minutes
$4.18
+56 975 370 786
+56 975 370 786
Call Contact via email
Flores Hermanos
Website
6h
Every 4 hours
$19.57–$25.00
+51 1 4800725
+51 1 4800725
Call Contact via email
Predilecto Tours
Website
5h
Once daily
+59 128 1779
+59 128 1779
Call Contact via email
Expreso Turismo San Martin Nobleza
Website
15h 30m
Twice daily
$21.74–$29.35
+51 051 602 943
+51 051 602 943
Call
Turbus
Website
28h 10m
3 times a day
$45.65–$184.78
+56 22 822 7500
+56 22 822 7500
Call Contact via email
Pullman San Andrés
Website
29h 20m
5 times a day
$41.30–$65.22
Ramos Cholele
Website
28h 50m
Twice daily
$43.48–$53.26
+56 57 226 9210
+56 57 226 9210
Call Contact via email
Pluss Chile
Website
29h 5m
3 times a day
$39.13–$64.13
+56 22 3813 550
+56 22 3813 550
Call Contact via email
Covalle Bus
26h 30m
Once daily
$47.33–$51.77
+56 51 221 3127
+56 51 221 3127
Call
Buses Horizonte
Website
28h
Once daily
$54.35–$76.09
+56 9 5869 8737
+56 9 5869 8737
Call
Jet Nort Super Class
Website
33h 2m
4 times a week
$71.22
+591 2527 7355
+591 2527 7355
Call Contact via email
Andoriña Tours
5h 30m
Once daily
$18.77
+51 993 585 217
+51 993 585 217
Call
Hallpa
Website
6h
Twice daily
$16.10
PeruRail
Website
PeruRail
Website
10h 20m
4 times a week
$239.13–$3,913.04
+51 1625 4848
+51 1625 4848
Call Contact via email

Questions and Answers

What is the cheapest way to get from Santiago to Cusco?

The cheapest way to get from Santiago to Cusco is to bus which costs $65.22 - $217.39 and takes 45h 12m.

What is the fastest way to get from Santiago to Cusco?

The fastest way to get from Santiago to Cusco is to fly which takes 6h 37m and costs $130.43 - $402.17 .

Is there a direct bus between Santiago and Cusco?

No, there is no direct bus from Santiago to Cusco. However, there are services departing from Terminal San Borja and arriving at Cusco via Terminal Internacional, Tacna and Arequipa. The journey, including transfers, takes approximately 42h 47m.

How far is it from Santiago to Cusco?

The distance between Santiago and Cusco is 2229 km. The road distance is 2878.3 km.

How do I travel from Santiago to Cusco without a car?

The best way to get from Santiago to Cusco without a car is to bus via Arequipa which takes 42h 47m and costs $76.09 - $228.26 .

How long does it take to get from Santiago to Cusco?

It takes approximately 6h 37m to get from Santiago to Cusco, including transfers.

Where do I catch the Santiago to Cusco bus from?

Santiago to Cusco bus services, operated by Turbus, depart from Terminal San Borja station.

Bus or fly from Santiago to Cusco?

The best way to get from Santiago to Cusco is to fly which takes 6h 37m and costs $130.43 - $402.17 . Alternatively, you can bus via Arequipa, which costs $76.09 - $228.26 and takes 42h 47m.

Where does the Santiago to Cusco bus arrive?

Santiago to Cusco bus services, operated by Turbus, arrive at Terminal Rodoviario de Arica station.

What is the time difference between Santiago and Cusco?

Cusco is 2h behind Santiago. It is currently 19:50 in Santiago and 17:50 in Cusco.

Can I drive from Santiago to Cusco?

Yes, the driving distance between Santiago to Cusco is 2878 km. It takes approximately 35h 31m to drive from Santiago to Cusco.
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