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How to Travel from

Mainz to Palermo

by Plane, Route or Car

Mainz
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Palermo
Transport search to Palermo
Mainz
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Palermo
Building a composite car route
Cheapest
Best Offer!
Car
27 h 50 min
1776 km.
from $97
Composite Route Car Only
Schedule

Mainz, Germany → Palermo, Italy

All
01 Jul 2026
July 2026
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August 2026
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November 2026
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December 2026
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January 2027
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February 2027
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May 2027
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June 2027
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All days
02 Jul, Thu
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05 Jul, Sun
06 Jul, Mon

Cheapest and Fastest Ways to Travel from Mainz to Palermo

Composite routes from Mainz to Palermo

Cheapest
Fastest
Other

Transport providers

Ryanair
Website
Lufthansa
Website
Eurowings
Website
Swiss
Website
Alitalia
Website
Ryanair
Website
2h 15m
Monday and Saturday
$50.63–$265.81
Lufthansa
Website
2h 10m
Thursday and Saturday
$291.13–$506.31
Eurowings
Website
2h 25m
Tuesday
$120.25–$379.73
Swiss
Website
4h 35m
Monday, Thursday, Saturday, and Sunday
$303.79–$886.04
Alitalia
Website
3h 50m
Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
$139.24–$329.10
FlixBus
Website
Autoservizi Salemi Srl
Website
SAIS Autolinee
Website
Busitalia Simet S.p.A.
Website
Satam Bus
Website
VRN
Website
FlixBus
Website
2h 25m
Twice daily
$20.25–$30.38
+49 30 300 137 300
+49 30 300 137 300
Call Contact via email
Autoservizi Salemi Srl
Website
21h 45m
Once daily
$40.50–$107.59
(+39) 0923 98.11.20
(+39) 0923 98.11.20
Call
SAIS Autolinee
Website
2h 30m
Every 3 hours
$12.66–$20.25
800 21 10 20
800 21 10 20
Call Contact via email
Busitalia Simet S.p.A.
Website
14h 50m
Once a week
$113.92–$139.24
+39 098 3520 315
+39 098 3520 315
Call Contact via email
Satam Bus
Website
3h 50m
4 times a day
$22.78–$32.91
+39 0871 344969
+39 0871 344969
Call Contact via email
VRN
Website
1h 15m
Every 3 hours
+49 621 - 1077 077
+49 621 - 1077 077
Call Contact via email
NS
Website
Deutsche Bahn Intercity-Express
Website
Nightjet
Website
ÖBB EuroCity
Website
Deutsche Bahn Regional
Website
Trenitalia Frecce
Website
ItaloTreno
Website
Trenitalia Intercity
Website
Swiss Railways (SBB/CFF/FFS)
Website
Süwex
Website
NS
Website
37 min
Twice daily
$20.25–$51.90
+31 30 751 5155
+31 30 751 5155
Call
Deutsche Bahn Intercity-Express
Website
43 min
Every 2 hours
$31.64–$35.44
+49 30 311-682904
+49 30 311-682904
Call
Nightjet
Website
6h 23m
Once daily
$62.02–$202.52
+43 51717
+43 51717
Call
ÖBB EuroCity
Website
2h 58m
5 times a week
$49.37–$69.62
+43 5 1717
+43 5 1717
Call
Deutsche Bahn Regional
Website
1h 21m
Hourly
$16.46–$24.05
+49 30 2970
+49 30 2970
Call
Trenitalia Frecce
Website
3h 12m
Every 30 minutes
$48.10–$151.89
+39 06 68475475
+39 06 68475475
Call
ItaloTreno
Website
3h 39m
Hourly
$48.06–$120.25
+39 06 8937 1892
+39 06 8937 1892
Call
Trenitalia Intercity
Website
7h 12m
Once daily
$40.50–$55.69
+39 06 68475475
+39 06 68475475
Call
Swiss Railways (SBB/CFF/FFS)
Website
1h 12m
Every 20 minutes
$40.50–$75.95
+41 848 44 66 88
+41 848 44 66 88
Call
Süwex
Website
50 min
Every 3 hours
$17.72–$24.05
0621 8301200
0621 8301200
Call
Grandi Navi Veloci
Website
Tirrenia
Website
Grandi Navi Veloci
Website
20h 45m
Once daily
$82.28–$202.52
+39 010 209 4591
+39 010 209 4591
Call Contact via email
Tirrenia
Website
10h 30m
Once daily
$50.63–$82.28
02 76028132
02 76028132
Call Contact via email

Questions and Answers

What is the cheapest way to get from Mainz to Palermo?

The cheapest way to get from Mainz to Palermo is to bus and bus and ferry which costs $92.39 - $173.91 and takes 34h 20m.

What is the fastest way to get from Mainz to Palermo?

The fastest way to get from Mainz to Palermo is to fly which takes 5h 36m and costs $130.43 - $271.74 .

Is there a direct bus between Mainz and Palermo?

No, there is no direct bus from Mainz station to Palermo. However, there are services departing from Mainz central train station and arriving at Palermo Terminal Bus via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 34h 20m.

Is there a direct train between Mainz and Palermo?

No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz, Hauptbahnhof and arriving at Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milan Centrale and Roma Termini. The journey, including transfers, takes approximately 25h 11m.

How far is it from Mainz to Palermo?

The distance between Mainz and Palermo is 1425 km.

How do I travel from Mainz to Palermo without a car?

The best way to get from Mainz to Palermo without a car is to train via Milan which takes 25h 11m and costs $250 - $500 .

How long does it take to get from Mainz to Palermo?

It takes approximately 5h 36m to get from Mainz to Palermo, including transfers.

Where do I catch the Mainz to Palermo bus from?

Mainz to Palermo bus services, operated by FlixBus, depart from Mainz central train station.

Where do I catch the Mainz to Palermo train from?

Mainz to Palermo train services, operated by Deutsche Bahn Intercity-Express, depart from Mainz, Hauptbahnhof station.

Train or fly from Mainz to Palermo?

The best way to get from Mainz to Palermo is to fly which takes 5h 36m and costs $130.43 - $271.74 . Alternatively, you can train via Milan, which costs $250 - $500 and takes 25h 11m.

Where does the Mainz to Palermo bus arrive?

Mainz to Palermo bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.

What is the time difference between Mainz and Palermo?

It is currently 10:25 at both, Mainz and Palermo.

Where does the Mainz to Palermo train arrive?

Mainz to Palermo train services, operated by Deutsche Bahn Intercity-Express, arrive at Mannheim, Hauptbahnhof station.

How do I get a train ticket from Mainz to Palermo?

Book your Mainz to Palermo train tickets online with Omio.

Where can I stay near Palermo?

There are 5321+ hotels available in Palermo. Prices start at $36.11 per night.
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