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How to Travel from

Rome to Santorini Mesotopos

by Plane, Train, Route or Car

Rome
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Santorini Mesotopos
Transport search to Santorini Mesotopos
Rome
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Santorini Mesotopos
Building a composite car route
Cheapest
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Car
34 h 56 min
2661 km.
from $146
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Schedule

Rome, Italy → Santorini Mesotopos, Greece

All
05 Apr 2026
April 2026
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December 2026
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Four ways to Travel from Rome to Santorini Mesotopos

Composite routes from Rome to Santorini Mesotopos

Cheapest
Other

Transport providers

Airlines

Vueling Airlines

Website:
vueling.com/
Plane from Leonardo Da Vinci–Fiumicino Airport to Santorini
Ave. Duration:
2h 15m
Frequency:
Tuesday and Saturday
Estimated price:
$65.22–$597.83

Ryanair

Website:
ryanair.com/
Plane from Leonardo Da Vinci–Fiumicino Airport to Santorini
Ave. Duration:
2h 10m
Frequency:
Sunday
Estimated price:
$35.87–$336.96
Plane from Naples International Airport to Santorini
Ave. Duration:
1h 55m
Frequency:
Friday
Estimated price:
$32.61–$315.22

easyJet

Website:
easyjet.com/
Plane from Naples International Airport to Santorini
Ave. Duration:
1h 55m
Frequency:
Monday
Estimated price:
$76.09–$413.04

Ulendo Airlink

Website:
flyulendo.com/
Plane from Leonardo Da Vinci–Fiumicino Airport to Santorini
Ave. Duration:
2h 15m
Frequency:
Monday and Thursday
Estimated price:
$29.35–$173.91

Volotea

Website:
volotea.com
Plane from Naples International Airport to Santorini
Ave. Duration:
1h 55m
Frequency:
Saturday
Estimated price:
$65.22–$315.22

Train operators

Trenitalia

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Roma Termini to Napoli
Ave. Duration:
3h 2m
Frequency:
Every 4 hours
Estimated price:
$13.04–$42.39

Trenitalia Frecce

Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Roma Termini to Napoli
Ave. Duration:
1h 8m
Frequency:
Every 30 minutes
Estimated price:
$19.57–$70.65
Train from Roma Termini to Foggia
Ave. Duration:
2h 57m
Frequency:
Every 4 hours
Estimated price:
$29.35–$92.39
Train from Roma Termini to Bari
Ave. Duration:
4h 15m
Frequency:
Every 4 hours
Estimated price:
$36.96–$119.57

ItaloTreno

Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Roma Termini to Napoli
Ave. Duration:
1h 13m
Frequency:
Hourly
Estimated price:
$42.39–$54.35
Train from Roma Termini to Foggia
Ave. Duration:
3h
Frequency:
5 times a day
Estimated price:
$54.35–$76.09
Train from Roma Termini to Bari
Ave. Duration:
4h 20m
Frequency:
5 times a day
Estimated price:
$65.22–$92.39

Trenitalia Intercity

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Roma Termini to Napoli
Ave. Duration:
2h 3m
Frequency:
Every 2 hours
Estimated price:
$15.22–$20.65
Train from Roma Termini to Foggia
Ave. Duration:
4h 57m
Frequency:
Once daily
Estimated price:
$23.91–$32.61
Train from Roma Termini to Bari
Ave. Duration:
6h 26m
Frequency:
Once daily
Estimated price:
$30.43–$42.39

Bus operators

Pistoia viaggi

Phone:
+393293958604
Website:
pistoia-viaggi.it
Bus from Roma, Autostazione Tiburtina to Durrës
Ave. Duration:
16h 15m
Frequency:
Once a week

Diamant Travel

Phone:
+355 69 617 8170
Website:
facebook.com/agjensiadiamant
Bus from Tirana, Terminali Lindor I Autobusave to Peiraias
Ave. Duration:
9h 45m
Frequency:
Once daily
Estimated price:
$42.42

Veli Trans

Phone:
+381 69 756756
Website:
facebook.com/D.o.o.VeliTrans
Bus from Foggia Station to Durrës
Ave. Duration:
9h 25m
Frequency:
Twice a week

Liko & Kosta Tours

Phone:
+355 69 661 4303
Website:
likokostatours.weebly.com/
Bus from Durrës to Ioannina
Ave. Duration:
3h 52m
Frequency:
Twice a week

M&B Travel

Phone:
+355697278670
Website:
facebook.com/mbtravel.durres
Bus from Bari Porto to Tirana
Ave. Duration:
6h 42m
Frequency:
3 times a week

Sita Sud

Phone:
+39 080 579 0211
Website:
sitasudtrasporti.it/
Bus from Napoli P.zza Garibaldi to Bari-Porto
Ave. Duration:
3h 15m
Frequency:
Once daily
Estimated price:
$13.04–$29.35

Anna Tours

Phone:
+355674053701
Website:
anna.tours/
Bus from Durrës to Piraeus
Ave. Duration:
12h
Frequency:
4 times a week
Estimated price:
$41.26

Maba Viaggi

Phone:
+355697580270
Website:
mabaviaggi.com/
Bus from Bari Centrale to Durrës
Ave. Duration:
12h
Frequency:
Twice a week

Siamos Tours

Phone:
0030 2108219900
Website:
siamostours.com/el/epikoinonia/
Bus from Kumanovo to Athens
Ave. Duration:
13h
Frequency:
3 times a week
Estimated price:
$39.13–$70.65

KTEL Irakleiou - Lasithiou S.A

Phone:
+30 2810 24 50 20
Website:
ktelherlas.gr/en/
Bus from Ioannina to Heraklion
Ave. Duration:
16h
Frequency:
Once daily
Estimated price:
$81.52–$119.57

Hak Bus

Phone:
+389 75 209 209
Website:
hakbus.org/
Bus from Roma Termini to Kumanovo
Ave. Duration:
21h 36m
Frequency:
Once a week
Estimated price:
$116.66

Komatas Tours Euro Interlines

Phone:
+355 68 407 6607
Website:
facebook.com/KomatasToursEuroInterlines
Bus from Durrës to Ioannina
Ave. Duration:
4h 35m
Frequency:
Once a week

Other operators

Seajets

Phone:
+30 210 4121001
Website:
seajets.com/
Other from Port of Piraeus to Athinios
Ave. Duration:
5h
Frequency:
Twice daily
Estimated price:
$81.52–$195.65
Other from Port of Piraeus to Syros
Ave. Duration:
2h 5m
Frequency:
Once daily
Estimated price:
$70.65–$130.43
Other from Syros to Athinios
Ave. Duration:
2h 45m
Frequency:
Once daily
Estimated price:
$70.65–$141.30
Other from Heraklion Port to Athinios
Ave. Duration:
1h 55m
Frequency:
Once daily
Estimated price:
$70.65–$119.57

Fast Ferries

Phone:
+30 210 4284000
Website:
fastferries.com.gr/
Other from Port of Piraeus to Athinios
Ave. Duration:
6h 45m
Frequency:
4 times a week
Estimated price:
$42.39–$293.48
Other from Port of Piraeus to Syros
Ave. Duration:
2h 20m
Frequency:
3 times a week
Estimated price:
$38.04–$152.17
Other from Syros to Athinios
Ave. Duration:
3h 55m
Frequency:
3 times a week
Estimated price:
$42.39–$173.91
Other from Heraklion Port to Athinios
Ave. Duration:
2h
Frequency:
3 times a week
Estimated price:
$33.70–$130.43

Golden Star Ferries

Phone:
+30 212 222 4000
Website:
goldenstarferries.gr/en/
Other from Port of Rafina to Athinios
Ave. Duration:
5h 20m
Frequency:
Once daily

Blue Star Ferries

Phone:
+302108919800
Website:
bluestarferries.com/en-gb/
Other from Bari M.ma to Igoumenitsa
Ave. Duration:
9h
Frequency:
Once daily
Estimated price:
$44.57–$108.70

Aegean Sea Lines

Phone:
+30 210 969 0950
Website:
aegean-sealines.gr/
Other from Port of Piraeus to Athinios
Ave. Duration:
8h 50m
Frequency:
3 times a week
Estimated price:
$81.52–$173.91

Ventouris Ferries

Phone:
+30 210 4828001
Website:
ventourisferries.com/en/
Other from Bari M.ma to Igoumenitsa
Ave. Duration:
11h 45m
Frequency:
4 times a week
Estimated price:
$61.18

Questions and Answers

What is the cheapest way to get from Rome to Santorini Mesotopos, Fira?

The cheapest way to get from Rome to Santorini Mesotopos, Fira is to fly which costs $108.70 - $358.70 and takes 4h 46m.

What is the fastest way to get from Rome to Santorini Mesotopos, Fira?

The fastest way to get from Rome to Santorini Mesotopos, Fira is to fly which takes 4h 46m and costs $108.70 - $358.70 .

How far is it from Rome to Santorini Mesotopos, Fira?

The distance between Rome and Santorini Mesotopos, Fira is 1322 km.

How do I travel from Rome to Santorini Mesotopos, Fira without a car?

The best way to get from Rome to Santorini Mesotopos, Fira without a car is to train and bus and car ferry via Naples which takes 30h 7m and costs .

How long does it take to get from Rome to Santorini Mesotopos, Fira?

It takes approximately 4h 46m to get from Rome to Santorini Mesotopos, Fira, including transfers.

Where can I stay near Santorini Mesotopos, Fira?

There are 2350+ hotels available in Santorini Mesotopos, Fira. Prices start at $63.62 per night.
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