How to Travel from
Isernia to Tuscany
by Bus or Car
Schedule
Isernia, Italy → Tuscany, Italy
All
11 Jun 2026
June 2026
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January 2027
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Cheapest and Fastest Ways to Travel from Isernia to Tuscany
Composite routes from Isernia to Tuscany
Cheapest
4 h 18 min
Car
412 km.
from $22
Route Navigator Isernia - Tuscany
Get all the information you need right here
Continue
4 м
4 м
Turn left onto Corso Giuseppe Garibaldi
Corso Giuseppe Garibaldi, 54 м
54 м
Keep right onto Via Libero Testa
Via Libero Testa, 243 м
243 м
Turn right onto Via Libero Testa
Via Libero Testa, 90 м
90 м
Turn right onto Piazza Gustino d'Uva
Piazza Gustino d'Uva, 79 м
79 м
Turn right onto Via Molise
Via Molise, 296 м
296 м
Turn left onto Via Laurelli
Via Laurelli, 65 м
65 м
Turn sharp right onto Corso Risorgimento
Corso Risorgimento, 172 м
172 м
Turn left onto Via Formichelli
Via Formichelli, 96 м
96 м
Turn right onto Via Giovanni Ventitreesimo
Via Giovanni Ventitreesimo, 210 м
210 м
Turn left onto Via Santo Spirito
Via Santo Spirito, 1 km 847 м
1 km 847 м
Keep right onto Via del Rio
Via del Rio, 59 м
59 м
Turn right
279 м
279 м
Turn slight right onto Strada Statale 85 Venafrana
Strada Statale 85 Venafrana, 13 km 99 м
13 km 99 м
At roundabout, take exit 2 onto Strada Statale 85 Venafrana
Strada Statale 85 Venafrana, 1 km 303 м
1 km 303 м
Keep right onto Strada Statale 85 Venafrana
Strada Statale 85 Venafrana, 18 km 324 м
18 km 324 м
Keep right onto SS6 Diramazione Via Casilina
SS6 Diramazione Via Casilina, 130 м
130 м
Continue onto Via Casilina
Via Casilina, 3 km 623 м
3 km 623 м
At roundabout, take exit 3 onto SS430
2 km 323 м
2 km 323 м
Keep right and take A1 toward Roma
Roma, A1, 253 м
253 м
Keep right and take A1 toward Roma
Roma, A1, 294 km 532 м
294 km 532 м
Keep right onto Svincolo di Valdichiana and drive toward Valdichiana, Bettolle, Sinalunga
Svincolo di Valdichiana, Valdichiana, Bettolle, Sinalunga, 491 м
491 м
Turn slight right onto Casello di Valdichiana and drive toward Valdichiana, Bettolle, Sinalunga
Casello di Valdichiana, Valdichiana, Bettolle, Sinalunga, 112 м
112 м
Keep right onto Casello di Valdichiana and take SP327 toward Arezzo, Siena, Perugia, Grosseto, Firenze, Roma, Foiano della Chiana, Sinalunga, Cortona, Castiglione del Lago, Assisi, Lago Trasimeno, Valdichiana Outlet Village
Casello di Valdichiana, Arezzo, Siena, Perugia, Grosseto, Firenze, Roma, Foiano della Chiana, Sinalunga, Cortona, Castiglione del Lago, Assisi, Lago Trasimeno, Valdichiana Outlet Village, SP327, 179 м
179 м
Continue onto SP327
463 м
463 м
At roundabout, take exit 2 onto Strada Provinciale di Foiano
Strada Provinciale di Foiano, 408 м
408 м
At roundabout, take exit 1 onto Svincolo di Bettolle
Svincolo di Bettolle, 44 km 347 м
44 km 347 м
At roundabout, take exit 1 onto Strada ANAS 394
Strada ANAS 394, 2 km 611 м
2 km 611 м
At roundabout, take exit 1 onto Strada Levante
Strada Levante, 1 km 518 м
1 km 518 м
At roundabout, take exit 1 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 706 м
1 km 706 м
At roundabout, take exit 2 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 30 м
1 km 30 м
At roundabout, take exit 2 onto Viale Pietro Toselli
Viale Pietro Toselli, 229 м
229 м
At roundabout, take exit 2 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 508 м
1 km 508 м
At roundabout, take exit 2 onto Viale Sardegna
Viale Sardegna, 1 km 615 м
1 km 615 м
At roundabout, take exit 1 onto Strada di Malizia
Strada di Malizia, 152 м
152 м
At roundabout, take exit 3 onto Viale Riccardo Lombardi
Viale Riccardo Lombardi, 1 km 575 м
1 km 575 м
At roundabout, take exit 2 onto Viale Giovanni Paolo Secondo
Viale Giovanni Paolo Secondo, 1 km 538 м
1 km 538 м
At roundabout, take exit 1 onto Viale Giovanni Paolo Secondo
Viale Giovanni Paolo Secondo, 1 km 221 м
1 km 221 м
At roundabout, take exit 1 onto Via Chiantigiana
Via Chiantigiana, 131 м
131 м
Keep left onto Via Toscana
Via Toscana, 412 м
412 м
At roundabout, take exit 2 onto Svincolo Siena Nord
Svincolo Siena Nord, 1 km 616 м
1 km 616 м
Keep right onto Svincolo Siena Nord and take RA3 toward Firenze
Svincolo Siena Nord, Firenze, RA3, 17 km 960 м
17 km 960 м
Keep right onto Svincolo di Colle Val d'Elsa Nord and take SS68 toward Colle di Val d'Elsa
Svincolo di Colle Val d'Elsa Nord, Colle di Val d'Elsa, SS68, 372 м
372 м
At roundabout, take exit 3
255 м
255 м
At roundabout, take exit 1 onto Strada Provinciale di Val di Cecina
Strada Provinciale di Val di Cecina, 2 km 482 м
2 km 482 м
Turn sharp left onto Strada Provinciale di Val di Cecina
Strada Provinciale di Val di Cecina, 31 м
31 м
Keep right onto Via Fortezza Medicea
Via Fortezza Medicea, 2 km 998 м
2 km 998 м
Turn left onto Via San Gimignano
Via San Gimignano, 220 м
220 м
At roundabout, take exit 3 onto Via dei Cipressi
Via dei Cipressi, 151 м
151 м
Keep left onto Strada Comunale del Cimitero
Strada Comunale del Cimitero, 178 м
178 м
Keep left onto Strada Comunale del Cimitero
Strada Comunale del Cimitero, 1 km 817 м
1 km 817 м
Keep left
143 м
143 м
Keep left
122 м
122 м
Arrive at destination
Transport providers
Bus operators
FlixBus
Bus from Isernia to Roma,
Ave. Duration:
3h
Frequency:
5 times a week
Estimated price:
$19.06–$27.95
Bus from Roma, Autostazione Tiburtina to Florence
Ave. Duration:
3h 35m
Frequency:
3 times a day
Estimated price:
$27.95–$39.38
Bus from Isernia to Florence
Ave. Duration:
6h 25m
Frequency:
5 times a week
Estimated price:
$43.19–$60.98
BlaBlaCar Bus
Phone:
+33 18 57 62 228
Website:
blablacar.co.uk/
Bus from Roma, Autostazione Tiburtina to Florence
Ave. Duration:
3h 45m
Frequency:
Once daily
Estimated price:
$26.68–$38.11
TTI Leonettibus SRL
Bus from Roma, Autostazione Tiburtina to Florence
Ave. Duration:
3h 45m
Frequency:
Once a week
Estimated price:
$16.52–$24.14
ATM Azienda di Trasporti Molisana S.p.A.
Bus from Isernia to Roma,
Ave. Duration:
2h 10m
Frequency:
3 times a day
Estimated price:
$10.80–$16.52
Airlines
Alitalia
Website:
alitalia.com/
Plane from Leonardo Da Vinci–Fiumicino Airport to Florence
Ave. Duration:
55 min
Frequency:
Every day
Estimated price:
$62.25–$343.02
Train operators
Trenitalia
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Isernia to Roma
Ave. Duration:
2h 22m
Frequency:
5 times a day
Estimated price:
$13.97–$43.19
Train from Roma Termini to Firenze
Ave. Duration:
3h 46m
Frequency:
Every 4 hours
Estimated price:
$17.79–$59.71
Trenitalia Frecce
Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Roma Termini to Firenze
Ave. Duration:
1h 36m
Frequency:
Every 30 minutes
Estimated price:
$26.68–$88.93
ItaloTreno
Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Roma Termini to Firenze
Ave. Duration:
1h 37m
Frequency:
Hourly
Estimated price:
$54.63–$76.23
Trenitalia Intercity
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Roma Termini to Firenze
Ave. Duration:
3h 10m
Frequency:
6 times a week
Estimated price:
$20.33–$29.22
Questions and Answers
What is the cheapest way to get from Isernia to Tuscany?
The cheapest way to get from Isernia to Tuscany is to bus via Rome which costs $22.83 - $59.78 and takes 6h 45m.
What is the fastest way to get from Isernia to Tuscany?
The fastest way to get from Isernia to Tuscany is to train which takes 4h 6m and costs $27.17 - $119.57 .
Is there a direct bus between Isernia and Tuscany?
No, there is no direct bus from Isernia to Tuscany. However, there are services departing from Isernia and arriving at Florence via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 45m.
Is there a direct train between Isernia and Tuscany?
No, there is no direct train from Isernia to Tuscany. However, there are services departing from Isernia and arriving at Firenze S.M.N. via Roma Termini. The journey, including transfers, takes approximately 4h 6m.
How far is it from Isernia to Tuscany?
The distance between Isernia and Tuscany is 447 km. The road distance is 429.7 km.
How do I travel from Isernia to Tuscany without a car?
The best way to get from Isernia to Tuscany without a car is to train which takes 4h 6m and costs $27.17 - $119.57 .
How long does it take to get from Isernia to Tuscany?
It takes approximately 4h 6m to get from Isernia to Tuscany, including transfers.
Where do I catch the Isernia to Tuscany bus from?
Isernia to Tuscany bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
Where do I catch the Isernia to Tuscany train from?
Isernia to Tuscany train services, operated by Trenitalia, depart from Isernia station.
Train or bus from Isernia to Tuscany?
The best way to get from Isernia to Tuscany is to train which takes 4h 6m and costs $27.17 - $119.57 . Alternatively, you can bus via Rome, which costs $22.83 - $59.78 and takes 6h 45m.
Where does the Isernia to Tuscany bus arrive?
Isernia to Tuscany bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Roma, Autostazione Tiburtina station.
Where does the Isernia to Tuscany train arrive?
Isernia to Tuscany train services, operated by Trenitalia, arrive at Roma Termini station.
Can I drive from Isernia to Tuscany?
Yes, the driving distance between Isernia to Tuscany is 430 km. It takes approximately 4h 12m to drive from Isernia to Tuscany.
How do I get a train ticket from Isernia to Tuscany?
Book your Isernia to Tuscany train tickets online with Omio.
How do I get a bus ticket from Isernia to Tuscany?
Book your Isernia to Tuscany bus tickets online with Omio and FlixBus.
Where can I stay near Tuscany?
There are 3020+ hotels available in Tuscany. Prices start at $41.36 per night.
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