How to Travel from
Domodossola to Siena
by Route or Car
Schedule
Domodossola, Italy → Siena, Italy
All
24 May 2026
May 2026
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July 2026
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August 2026
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September 2026
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December 2026
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25 May, Mon
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Cheapest and Fastest Ways to Travel from Domodossola to Siena
Composite routes from Domodossola to Siena
Cheapest
4 h 57 min
Car
492 km.
from $27
Other
5 h 34 min
392 km.
from $5.43
9 h 30 min
392 km.
from $43.52
8 h 41 min
Train, Plane
390 km.
from $223.37
6 h 53 min
Train, Bus
390 km.
Select a ticket
Transport providers
Airlines
Austrian Airlines
Website:
austrian.com/?sc_lang=en&cc=ZZ
Plane from Malpensa International Airport to Florence
Ave. Duration:
4h 10m
Frequency:
Monday, Wednesday, Friday, and Sunday
Estimated price:
$419.24–$1,143.39
Swiss
Website:
swiss.com/
Plane from Malpensa International Airport to Florence
Ave. Duration:
3h 45m
Frequency:
Every day
Estimated price:
$355.72–$1,016.34
Air Dolomiti
Website:
airdolomiti.it/
Plane from Malpensa International Airport to Florence
Ave. Duration:
4h 50m
Frequency:
Every day
Estimated price:
$520.88–$1,143.39
Alitalia
Website:
alitalia.com/
Plane from Malpensa International Airport to Florence
Ave. Duration:
3h 50m
Frequency:
Every day
Estimated price:
$82.58–$381.13
Train operators
Trenitalia
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Domodossola to Busto
Ave. Duration:
1h 45m
Frequency:
Every 4 hours
Estimated price:
$7.62–$20.33
Train from Firenze S.M.N. to Siena
Ave. Duration:
1h 30m
Frequency:
Hourly
Estimated price:
$8.26–$21.60
Train from Domodossola to Milano
Ave. Duration:
2h 13m
Frequency:
Every 4 hours
Estimated price:
$9.53–$27.95
Trenitalia Frecce
Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Milan Centrale to Firenze
Ave. Duration:
1h 54m
Frequency:
Hourly
Estimated price:
$29.22–$101.63
Train from Milano P.Garibaldi to Firenze
Ave. Duration:
2h 2m
Frequency:
Every 4 hours
Estimated price:
$29.22–$101.63
ItaloTreno
Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Milan Centrale to Firenze
Ave. Duration:
1h 55m
Frequency:
Hourly
Estimated price:
$60.98–$82.58
Trenitalia Intercity
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Milan Centrale to Firenze
Ave. Duration:
3h 42m
Frequency:
6 times a week
Estimated price:
$24.14–$33.03
Trenord
Train from Domodossola to Milano
Ave. Duration:
1h 44m
Frequency:
Every 3 hours
Estimated price:
$10.16–$13.97
Train from Domodossola to Busto
Ave. Duration:
1h 6m
Frequency:
Every 3 hours
Estimated price:
$8.26–$10.80
Bus operators
Itabus
Phone:
+39 06 88 93 82 32
Website:
itabus.it/en/home
Bus from Milan Malpensa Airport to Siena
Ave. Duration:
7h 10m
Frequency:
Once daily
Estimated price:
$20.33–$29.22
Autoservizi Comazzi srl
Bus from Domodossola - Stazione Ferroviaria to Aeroporto
Ave. Duration:
1h 20m
Frequency:
Every 4 hours
Estimated price:
$10.63
Autolinee Toscane - Linee Regionali
Bus from Firenze Autostazione to Siena-Via
Ave. Duration:
1h 15m
Frequency:
Hourly
Questions and Answers
What is the cheapest way to get from Domodossola to Siena?
The cheapest way to get from Domodossola to Siena is to bus which costs $26.09 - $34.78 and takes 9h 30m.
What is the fastest way to get from Domodossola to Siena?
The fastest way to get from Domodossola to Siena is to drive which takes 4h 55m and costs $86.96 - $130.43 .
Is there a direct bus between Domodossola and Siena?
No, there is no direct bus from Domodossola to Siena station. However, there are services departing from Domodossola - Stazione Ferroviaria and arriving at Siena Central Train Station via Milan Malpensa Airport. The journey, including transfers, takes approximately 9h 30m.
How far is it from Domodossola to Siena?
The distance between Domodossola and Siena is 496 km. The road distance is 492.5 km.
How do I travel from Domodossola to Siena without a car?
The best way to get from Domodossola to Siena without a car is to train and bus via Milan which takes 5h 34m and costs .
How long does it take to get from Domodossola to Siena?
It takes approximately 5h 34m to get from Domodossola to Siena, including transfers.
Where do I catch the Domodossola to Siena bus from?
Domodossola to Siena bus services, operated by Autoservizi Comazzi srl, depart from Domodossola - Stazione Ferroviaria station.
Where does the Domodossola to Siena bus arrive?
Domodossola to Siena bus services, operated by Autoservizi Comazzi srl, arrive at Aeroporto Malpensa - Terminal 1 station.
Can I drive from Domodossola to Siena?
Yes, the driving distance between Domodossola to Siena is 493 km. It takes approximately 4h 55m to drive from Domodossola to Siena.
Where can I stay near Siena?
There are 2040+ hotels available in Siena. Prices start at $30.01 per night.
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