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How to Travel from

Florence to Sistine Chapel

by Plane, Train, Bus, Route or Car

Florence
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Sistine Chapel
Transport search to Sistine Chapel
Florence
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Sistine Chapel
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Cheapest
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Car
2 h 47 min
278 km.
from $15
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Schedule

Florence, Italy → Sistine Chapel, The Vatican

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May 2026
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Cheapest and Fastest Ways to Travel from Florence to Sistine Chapel

Composite routes from Florence to Sistine Chapel

Cheapest
Fastest
Other

Transport providers

Bus operators

FlixBus

Phone:
+49 30 300 137 300
Website:
flixbus.com
Bus from Florence to Roma,
Ave. Duration:
3h 15m
Frequency:
Hourly
Estimated price:
$27.95–$39.38

BlaBlaCar Bus

Phone:
+33 18 57 62 228
Website:
blablacar.co.uk/
Bus from Florence to Roma,
Ave. Duration:
3h 25m
Frequency:
Once daily
Estimated price:
$26.68–$38.11

Itabus

Phone:
+39 06 88 93 82 32
Website:
itabus.it/en/home
Bus from Florence to Roma,
Ave. Duration:
3h 50m
Frequency:
Hourly
Estimated price:
$13.97–$20.33

Marino Autolinee

Phone:
+39 080 3112335
Website:
marinobus.it/
Bus from Florence to Roma,
Ave. Duration:
4h 5m
Frequency:
Once daily
Estimated price:
$31.76–$43.19

Autoservizi Salemi Srl

Phone:
(+39) 0923 98.11.20
Website:
autoservizisalemi.it/en/
Bus from Florence to Roma,
Ave. Duration:
4h 15m
Frequency:
Once daily
Estimated price:
$15.25–$22.87

Airlines

Alitalia

Website:
alitalia.com/
Plane from Florence Peretola Airport to Leonardo
Ave. Duration:
52 min
Frequency:
Every day
Estimated price:
$62.25–$343.02
Plane from Bologna Guglielmo Marconi Airport to Leonardo
Ave. Duration:
1h 1m
Frequency:
Every day
Estimated price:
$53.36–$228.68

Train operators

Trenitalia

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
4h 16m
Frequency:
Once daily
Estimated price:
$17.79–$59.71
Train from Firenze Campo Marte to Roma
Ave. Duration:
3h 38m
Frequency:
Every 4 hours
Estimated price:
$19.06–$69.87
Train from Firenze S.M.N. to Bologna
Ave. Duration:
1h 28m
Frequency:
Twice daily
Estimated price:
$7.62–$21.60

Trenitalia Frecce

Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 37m
Frequency:
Every 30 minutes
Estimated price:
$26.68–$88.93
Train from Firenze Campo Marte to Roma
Ave. Duration:
1h 25m
Frequency:
Twice daily
Estimated price:
$27.95–$95.28
Train from Firenze S.M.N. to Bologna
Ave. Duration:
38 min
Frequency:
Every 30 minutes
Estimated price:
$12.70–$55.90

ItaloTreno

Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 36m
Frequency:
Hourly
Estimated price:
$54.63–$76.23
Train from Firenze S.M.N. to Bologna
Ave. Duration:
39 min
Frequency:
Hourly
Estimated price:
$35.57–$44.47

Trenitalia Intercity

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
2h 35m
Frequency:
6 times a week
Estimated price:
$20.33–$29.22
Train from Firenze Campo Marte to Roma
Ave. Duration:
2h 57m
Frequency:
Twice daily
Estimated price:
$22.87–$30.49
Train from Firenze S.M.N. to Bologna
Ave. Duration:
1h 17m
Frequency:
Once daily
Estimated price:
$9.53–$12.70

ATAC S.p.A. Azienda per la mobilità

Phone:
+39 06 46951
Website:
atac.roma.it/
Bus from Termini to Cavalleggeri/S.
Ave. Duration:
28 min
Frequency:
Every 5 minutes
Estimated price:
$1.87–$8.68

Questions and Answers

What is the cheapest way to get from Florence to Sistine Chapel?

The cheapest way to get from Florence to Sistine Chapel is to bus which costs $13.04 - $44.57 and takes 4h 19m.

What is the fastest way to get from Florence to Sistine Chapel?

The fastest way to get from Florence to Sistine Chapel is to train and line 64 bus which takes 2h 14m and costs $17.39 - $86.96 .

Is there a direct bus between Florence and Sistine Chapel?

No, there is no direct bus from Florence to Sistine Chapel. However, there are services departing from Florence and arriving at Emo via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 19m.

How far is it from Florence to Sistine Chapel?

The distance between Florence and Sistine Chapel is 267 km. The road distance is 277.6 km.

How do I travel from Florence to Sistine Chapel without a car?

The best way to get from Florence to Sistine Chapel without a car is to train and line 64 bus which takes 2h 14m and costs $17.39 - $86.96 .

How long does it take to get from Florence to Sistine Chapel?

It takes approximately 2h 14m to get from Florence to Sistine Chapel, including transfers.

Where do I catch the Florence to Sistine Chapel bus from?

Florence to Sistine Chapel bus services, operated by FlixBus, depart from Florence station.

Train, bus or fly from Florence to Sistine Chapel?

The best way to get from Florence to Sistine Chapel is to bus which takes 4h 19m and costs $13.04 - $44.57 . Alternatively, you can fly, which costs $59.78 - $250 and takes 3h 13m, you could also train, which costs $18.48 - $86.96 and takes 4h 15m.

Where does the Florence to Sistine Chapel bus arrive?

Florence to Sistine Chapel bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.

Can I drive from Florence to Sistine Chapel?

Yes, the driving distance between Florence to Sistine Chapel is 278 km. It takes approximately 2h 43m to drive from Florence to Sistine Chapel.

Where can I stay near Sistine Chapel?

There are 20490+ hotels available in Sistine Chapel. Prices start at $34.99 per night.
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