HUB hero image

How to Travel from

Florence to Isernia

by Bus or Car

Florence
→
+0 →
Isernia
Transport search to Isernia
Simply select points
A and B, and we will create
a convenient route for you 👍
Italy Florence Isernia
Florence
→
+0 →
Isernia
Building a composite car route
Simply select points
A and B, and we will create
a convenient route for you 👍
To build a composite route, click the "Add point" button.
You can also move and delete intermediate points.
Cheapest
Best Offer!
Car
4 h 7 min
429 km.
from $23
Composite Route Car Only
Schedule

Florence, Italy → Isernia, Italy

All
20 Jun 2026
June 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
July 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
August 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
27
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
September 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
October 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
November 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
26
27
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
6
December 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
January 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
February 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
March 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
April 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
May 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
26
27
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
All days
21 Jun, Sun
22 Jun, Mon
23 Jun, Tue
24 Jun, Wed
25 Jun, Thu

Cheapest and Fastest Ways to Travel from Florence to Isernia

Composite routes from Florence to Isernia

Cheapest
4 h 7 min
Car
429 km.
from $23

Transport providers

Bus operators

FlixBus

Phone:
+49 30 300 137 300
Email:
Website:
flixbus.com
Bus from Florence to Isernia
Ave. Duration:
6h 5m
Frequency:
5 times a week
Estimated price:
$43.19–$60.98

Curcio Viaggi

Phone:
+39 089 233 899
Email:
Website:
autolineecurcio.it/
Bus from Florence - Villa Costanza to Cassino
Ave. Duration:
4h 55m
Frequency:
Once daily
Estimated price:
$1.99

ATM Azienda di Trasporti Molisana S.p.A.

Phone:
+39 0874 64744
Email:
Website:
atm-molise.it/linee/
Bus from Cassino Piazza Garibaldi to Isernia
Ave. Duration:
58 min
Frequency:
3 times a day
Estimated price:
$3.30–$4.83

Airlines

easyJet

Website:
easyjet.com/
Plane from Florence Peretola Airport to Naples
Ave. Duration:
3h 37m
Frequency:
Monday, Wednesday, and Thursday
Estimated price:
$107.99–$431.95

Volotea

Website:
volotea.com
Plane from Florence Peretola Airport to Naples
Ave. Duration:
3h 10m
Frequency:
Monday, Thursday, Friday, and Sunday
Estimated price:
$107.99–$431.95

Alitalia

Website:
alitalia.com/
Plane from Florence Peretola Airport to Naples
Ave. Duration:
3h 30m
Frequency:
Every day
Estimated price:
$152.45–$546.28
Plane from Florence Peretola Airport to Leonardo
Ave. Duration:
52 min
Frequency:
Every day
Estimated price:
$62.25–$343.02

Train operators

Trenitalia

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
4h 5m
Frequency:
Once daily
Estimated price:
$17.79–$59.71
Train from Roma Tiburtina to Isernia
Ave. Duration:
2h 16m
Frequency:
6 times a week
Estimated price:
$13.97–$43.19
Train from Napoli Centrale to Isernia
Ave. Duration:
1h 57m
Frequency:
4 times a day
Estimated price:
$10.16–$29.22
Train from Roma Termini to Isernia
Ave. Duration:
2h 12m
Frequency:
5 times a day
Estimated price:
$13.97–$43.19

Trenitalia Frecce

Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 26m
Frequency:
Every 30 minutes
Estimated price:
$25.41–$88.93

ItaloTreno

Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 27m
Frequency:
Hourly
Estimated price:
$54.63–$69.87

Trenitalia Intercity

Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
2h 35m
Frequency:
6 times a week
Estimated price:
$20.33–$29.22

Questions and Answers

What is the cheapest way to get from Florence to Isernia?

The cheapest way to get from Florence to Isernia is to bus via Cassino which costs $4.46 - $5.98 and takes 6h 59m.

What is the fastest way to get from Florence to Isernia?

The fastest way to get from Florence to Isernia is to drive which takes 4h 7m and costs $76.09 - $119.57 .

Is there a direct bus between Florence and Isernia?

Yes, there is a direct bus departing from Florence and arriving at Isernia. Services depart five times a week, and operate Monday, Tuesday, Friday, Saturday and Sunday. The journey takes approximately 6h 5m.

Is there a direct train between Florence and Isernia?

No, there is no direct train from Florence to Isernia. However, there are services departing from Firenze S.M.N. and arriving at Isernia via Roma Tiburtina. The journey, including transfers, takes approximately 4h 42m.

How far is it from Florence to Isernia?

The distance between Florence and Isernia is 441 km. The road distance is 428.1 km.

How do I travel from Florence to Isernia without a car?

The best way to get from Florence to Isernia without a car is to train which takes 4h 42m and costs $27.17 - $119.57 .

How long does it take to get from Florence to Isernia?

It takes approximately 4h 42m to get from Florence to Isernia, including transfers.

Where do I catch the Florence to Isernia bus from?

Florence to Isernia bus services, operated by FlixBus, depart from Florence station.

Where do I catch the Florence to Isernia train from?

Florence to Isernia train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.

Train or bus from Florence to Isernia?

The best way to get from Florence to Isernia is to train which takes 4h 42m and costs $27.17 - $119.57 . Alternatively, you can bus, which costs $36.96 - $52.17 and takes 6h 5m.

Where does the Florence to Isernia bus arrive?

Florence to Isernia bus services, operated by FlixBus, arrive at Isernia station.

Where does the Florence to Isernia train arrive?

Florence to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Tiburtina station.

Can I drive from Florence to Isernia?

Yes, the driving distance between Florence to Isernia is 428 km. It takes approximately 4h 7m to drive from Florence to Isernia.

How do I get a train ticket from Florence to Isernia?

Book your Florence to Isernia train tickets online with Omio.

How do I get a bus ticket from Florence to Isernia?

Book your Florence to Isernia bus tickets online with Omio and FlixBus.

Where can I stay near Isernia?

There are 352+ hotels available in Isernia. Prices start at $28.95 per night.
→
+0 →
Transport search
Transport search