How to Travel from
Pisa to Isernia
by Route or Car
Schedule
Pisa, Italy → Isernia, Italy
All
10 Jun 2026
June 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
July 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
August 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
27
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
September 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
October 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
November 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
26
27
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
6
December 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
January 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
February 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
March 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
April 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
May 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
26
27
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
All days
11 Jun, Thu
12 Jun, Fri
13 Jun, Sat
14 Jun, Sun
15 Jun, Mon
Cheapest and Fastest Ways to Travel from Pisa to Isernia
Composite routes from Pisa to Isernia
Cheapest
5 h 4 min
Car
525 km.
from $28
Other
6 h 3 min
390 km.
from $84.98
9 h 24 min
390 km.
from $7.43
7 h 40 min
390 km.
from $53.35
6 h 38 min
Bus, Plane
390 km.
from $159.40
6 h 8 min
390 km.
from $93.78
7 h 9 min
Train, Plane
390 km.
from $152.01
8 h 21 min
Train, Plane
390 km.
from $149.29
Route Navigator Pisa - Isernia
Get all the information you need right here
Continue onto Lungarno Gambacorti
Lungarno Gambacorti, 1 km 554 м
1 km 554 м
Turn left onto Via Porta a Mare
Via Porta a Mare, 57 м
57 м
Keep left onto Via Porta a Mare
Via Porta a Mare, 21 м
21 м
At roundabout, take exit 2 onto Via Porta a Mare
Via Porta a Mare, 436 м
436 м
At roundabout, take exit 1 onto Via Cesare Battisti
Via Cesare Battisti, 173 м
173 м
At roundabout, take exit 1 onto Via Cesare Battisti
Via Cesare Battisti, 93 м
93 м
At roundabout, take exit 1 onto Viale Antonio Gramsci
Viale Antonio Gramsci, 362 м
362 м
Turn right onto Cavalcavia San Giusto
Cavalcavia San Giusto, 185 м
185 м
Turn right onto Cavalcavia San Giusto
Cavalcavia San Giusto, 1 km 568 м
1 km 568 м
At roundabout, take exit 2 onto Via dell'Aeroporto
Via dell'Aeroporto, 354 м
354 м
Turn sharp left onto Via Eugenio III
Via Eugenio III, 171 м
171 м
At roundabout, take exit 1 onto Via Eugenio III
Via Eugenio III, 267 м
267 м
At roundabout, take exit 2 onto Rotatoria Quarantaseiesima (46°) Brigata Aerea
Rotatoria Quarantaseiesima (46°) Brigata Aerea, 16 km 621 м
16 km 621 м
Continue onto Strada di Grande Comunicazione Firenze-Pisa-Livorno and take Fi-Pi-Li, A1 toward Firenze, Empoli, Volterra
Strada di Grande Comunicazione Firenze-Pisa-Livorno, Firenze, Empoli, Volterra, Fi-Pi-Li, A1, 56 km 444 м
56 km 444 м
Keep right
1 km 44 м
1 km 44 м
Keep left
392 km 210 м
392 km 210 м
Keep right and drive toward San Vittore, Terme di Sulo, Castelforte, Conca della Campania, Sessa Aurunca, Venafro, Isernia, Campobasso, Agnone, Castel di Sangro, Roccaraso, S.M.I. Montelungo
San Vittore, Terme di Sulo, Castelforte, Conca della Campania, Sessa Aurunca, Venafro, Isernia, Campobasso, Agnone, Castel di Sangro, Roccaraso, S.M.I. Montelungo, 1 km 854 м
1 km 854 м
Keep left
45 м
45 м
Turn left onto Strada Regionale 430 della Valle del Garigliano Ex SS 430
Strada Regionale 430 della Valle del Garigliano Ex SS 430, 2 km 325 м
2 km 325 м
At roundabout, take exit 1 onto Via Casilina
Via Casilina, 3 km 736 м
3 km 736 м
Keep left onto SS6 Diramazione Via Casilina
SS6 Diramazione Via Casilina, 20 km 741 м
20 km 741 м
At roundabout, take exit 1 onto Strada Statale 85 Venafrana
Strada Statale 85 Venafrana, 13 km 113 м
13 km 113 м
Keep right and drive toward Isernia Santo Spirito
Isernia Santo Spirito, 206 м
206 м
Keep left and drive toward Isernia Santo Spirito
Isernia Santo Spirito, 49 м
49 м
Turn left onto Via del Rio
Via del Rio, 148 м
148 м
Keep right onto Via Santo Spirito
Via Santo Spirito, 1 km 761 м
1 km 761 м
Continue onto Via Don Luigi Sturzo
Via Don Luigi Sturzo, 217 м
217 м
Turn right onto Corso Giuseppe Garibaldi
Corso Giuseppe Garibaldi, 1 km 743 м
1 km 743 м
Turn sharp left
4 м
4 м
Arrive at destination
Transport providers
Airlines
Ryanair
Website:
ryanair.com/
Plane from Galileo Galilei International Airport to Naples
Ave. Duration:
3h 50m
Frequency:
Monday, Thursday, Friday, Saturday, and Sunday
Estimated price:
$55.90–$368.41
Plane from Genoa Cristoforo Colombo Airport to Naples
Ave. Duration:
1h 20m
Frequency:
Monday and Friday
Estimated price:
$50.81–$635.18
easyJet
Website:
easyjet.com/
Plane from Galileo Galilei International Airport to Naples
Ave. Duration:
3h 40m
Frequency:
Monday, Wednesday, Friday, Saturday, and Sunday
Estimated price:
$55.90–$368.41
Volotea
Website:
volotea.com
Plane from Genoa Cristoforo Colombo Airport to Naples
Ave. Duration:
1h 25m
Frequency:
Thursday and Sunday
Estimated price:
$33.03–$292.18
Alitalia
Website:
alitalia.com/
Plane from Florence Peretola Airport to Leonardo
Ave. Duration:
52 min
Frequency:
Every day
Estimated price:
$62.25–$343.00
Plane from Genoa Cristoforo Colombo Airport to Naples
Ave. Duration:
3h 25m
Frequency:
Every day
Estimated price:
$76.22–$343.00
Bus operators
FlixBus
Bus from Pisa to Roma,
Ave. Duration:
4h 30m
Frequency:
6 times a week
Estimated price:
$36.84–$50.81
Bus from Roma, Autostazione Tiburtina to Isernia
Ave. Duration:
2h 35m
Frequency:
5 times a week
Estimated price:
$19.06–$27.95
Curcio Viaggi
Bus from Pisa to Cassino
Ave. Duration:
7h 20m
Frequency:
Once daily
Estimated price:
$1.99
ATM Azienda di Trasporti Molisana S.p.A.
Bus from Roma, Autostazione Tiburtina to Isernia
Ave. Duration:
2h 10m
Frequency:
3 times a day
Estimated price:
$10.80–$16.51
Bus from Cassino Piazza Garibaldi to Isernia
Ave. Duration:
58 min
Frequency:
3 times a day
Estimated price:
$3.30–$4.83
Train operators
Trenitalia
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Pisa Centrale to Firenze
Ave. Duration:
1h 1m
Frequency:
Every 30 minutes
Estimated price:
$6.99–$19.06
Train from Firenze S.M.N. to Roma
Ave. Duration:
4h 16m
Frequency:
Once daily
Estimated price:
$17.79–$59.71
Train from Roma Termini to Isernia
Ave. Duration:
2h 12m
Frequency:
5 times a day
Estimated price:
$13.97–$43.19
Train from Napoli Centrale to Isernia
Ave. Duration:
1h 57m
Frequency:
4 times a day
Estimated price:
$10.16–$29.22
Train from Pisa Centrale to Roma
Ave. Duration:
4h 3m
Frequency:
Every 4 hours
Estimated price:
$22.87–$76.22
Trenitalia Frecce
Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 42m
Frequency:
Every 30 minutes
Estimated price:
$26.68–$88.93
Train from Pisa Centrale to Roma
Ave. Duration:
2h 56m
Frequency:
Every 4 hours
Estimated price:
$31.76–$107.98
Train from Pisa Centrale to Genova
Ave. Duration:
1h 47m
Frequency:
Every 4 hours
Estimated price:
$17.79–$69.87
ItaloTreno
Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 36m
Frequency:
Hourly
Estimated price:
$54.63–$76.22
Trenitalia Intercity
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
2h 40m
Frequency:
6 times a week
Estimated price:
$20.33–$29.22
Train from Pisa Centrale to Roma
Ave. Duration:
3h 13m
Frequency:
Twice daily
Estimated price:
$25.41–$35.57
Train from Pisa Centrale to Genova
Ave. Duration:
3h 10m
Frequency:
Every 4 hours
Estimated price:
$13.97–$19.06
Questions and Answers
What is the cheapest way to get from Pisa to Isernia?
The cheapest way to get from Pisa to Isernia is to bus which costs $4.46 - $5.98 and takes 9h 24m.
What is the fastest way to get from Pisa to Isernia?
The fastest way to get from Pisa to Isernia is to drive which takes 5h and costs $92.39 - $141.30 .
Is there a direct bus between Pisa and Isernia?
No, there is no direct bus from Pisa to Isernia. However, there are services departing from Pisa and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 7h 40m.
Is there a direct train between Pisa and Isernia?
No, there is no direct train from Pisa to Isernia. However, there are services departing from Pisa Centrale and arriving at Isernia via Firenze S.M.N. and Roma Termini. The journey, including transfers, takes approximately 6h 3m.
How far is it from Pisa to Isernia?
The distance between Pisa and Isernia is 525 km. The road distance is 531.3 km.
How do I travel from Pisa to Isernia without a car?
The best way to get from Pisa to Isernia without a car is to train via Florence which takes 6h 3m and costs $32.61 - $130.43 .
How long does it take to get from Pisa to Isernia?
It takes approximately 6h 3m to get from Pisa to Isernia, including transfers.
Where do I catch the Pisa to Isernia bus from?
Pisa to Isernia bus services, operated by FlixBus, depart from Pisa station.
Where do I catch the Pisa to Isernia train from?
Pisa to Isernia train services, operated by Trenitalia, depart from Pisa Centrale station.
Train or bus from Pisa to Isernia?
The best way to get from Pisa to Isernia is to train via Florence which takes 6h 3m and costs $32.61 - $130.43 . Alternatively, you can bus via Rome, which costs $40.22 - $70.65 and takes 7h 40m.
Where does the Pisa to Isernia bus arrive?
Pisa to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Where does the Pisa to Isernia train arrive?
Pisa to Isernia train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Can I drive from Pisa to Isernia?
Yes, the driving distance between Pisa to Isernia is 531 km. It takes approximately 5h to drive from Pisa to Isernia.
How do I get a train ticket from Pisa to Isernia?
Book your Pisa to Isernia train tickets online with Omio.
How do I get a bus ticket from Pisa to Isernia?
Book your Pisa to Isernia bus tickets online with Omio and FlixBus.
Where can I stay near Isernia?
There are 352+ hotels available in Isernia. Prices start at $28.95 per night.
→
+0
→
Transport search
Transport search
From Pisa, where will you go next? Select a city below to get started
Popular routes
Choose one of the options below and start your journey