How to Travel from
Siena to Isernia
by Route or Car
Schedule
Siena, Italy → Isernia, Italy
All
02 Jul 2026
July 2026
Mon
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August 2026
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September 2026
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October 2026
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November 2026
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December 2026
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January 2027
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February 2027
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April 2027
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May 2027
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June 2027
Mon
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All days
03 Jul, Fri
04 Jul, Sat
05 Jul, Sun
06 Jul, Mon
07 Jul, Tue
Cheapest and Fastest Ways to Travel from Siena to Isernia
Composite routes from Siena to Isernia
Cheapest
3 h 47 min
Car
383 km.
from $21
Other
5 h 44 min
304 km.
from $7.43
6 h 12 min
Bus, Train
304 km.
from $5.43
8 h 51 min
Bus, Plane, Train
303 km.
Select a ticket
6 h
304 km.
from $37
7 h 32 min
303 km.
from $70.43
Route Navigator Siena - Isernia
Get all the information you need right here
Continue
497 м
497 м
Continue onto Viale Don Giovanni Minzoni
Viale Don Giovanni Minzoni, 97 м
97 м
Turn right onto Via Lippo Memmi
Via Lippo Memmi, 272 м
272 м
Turn left onto Via Lorenzo Maitani
Via Lorenzo Maitani, 93 м
93 м
Turn left onto Via Lorenzo Maitani
Via Lorenzo Maitani, 83 м
83 м
Turn right onto Via Simone Martini
Via Simone Martini, 70 м
70 м
At roundabout, take exit 1 onto Via Simone Martini
Via Simone Martini, 1 km 639 м
1 km 639 м
At roundabout, take exit 3 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 47 м
1 km 47 м
At roundabout, take exit 2 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 726 м
1 km 726 м
At roundabout, take exit 3 onto Strada Levante
Strada Levante, 1 km 529 м
1 km 529 м
At roundabout, take exit 2 onto Strada Levante
Strada Levante, 2 km 592 м
2 km 592 м
At roundabout, take exit 2 onto Raccordo Autostradale Siena-Bettolle
Raccordo Autostradale Siena-Bettolle, 43 km 237 м
43 km 237 м
Keep right onto Svincolo di Bettolle and drive toward Bettolle, A1 Firenze-Roma
Svincolo di Bettolle, Bettolle, A1 Firenze-Roma, 491 м
491 м
At roundabout, take exit 2 onto Casello di Valdichiana
Casello di Valdichiana, 271 м
271 м
Keep right onto Svincolo di Valdichiana and take A1 toward Roma
Svincolo di Valdichiana, Roma, A1, 293 km 335 м
293 km 335 м
Keep right and drive toward San Vittore, Terme di Sulo, Castelforte, Conca della Campania, Sessa Aurunca, Venafro, Isernia, Campobasso, Agnone, Castel di Sangro, Roccaraso, S.M.I. Montelungo
San Vittore, Terme di Sulo, Castelforte, Conca della Campania, Sessa Aurunca, Venafro, Isernia, Campobasso, Agnone, Castel di Sangro, Roccaraso, S.M.I. Montelungo, 1 km 854 м
1 km 854 м
Keep left
45 м
45 м
Turn left onto Strada Regionale 430 della Valle del Garigliano Ex SS 430
Strada Regionale 430 della Valle del Garigliano Ex SS 430, 2 km 325 м
2 km 325 м
At roundabout, take exit 1 onto Via Casilina
Via Casilina, 3 km 736 м
3 km 736 м
Keep left onto SS6 Diramazione Via Casilina
SS6 Diramazione Via Casilina, 20 km 741 м
20 km 741 м
At roundabout, take exit 1 onto Strada Statale 85 Venafrana
Strada Statale 85 Venafrana, 13 km 113 м
13 km 113 м
Keep right and drive toward Isernia Santo Spirito
Isernia Santo Spirito, 206 м
206 м
Keep left and drive toward Isernia Santo Spirito
Isernia Santo Spirito, 49 м
49 м
Turn left onto Via del Rio
Via del Rio, 148 м
148 м
Keep right onto Via Santo Spirito
Via Santo Spirito, 1 km 761 м
1 km 761 м
Continue onto Via Don Luigi Sturzo
Via Don Luigi Sturzo, 217 м
217 м
Turn right onto Corso Giuseppe Garibaldi
Corso Giuseppe Garibaldi, 1 km 743 м
1 km 743 м
Turn sharp left
4 м
4 м
Arrive at destination
Transport providers
Bus operators
Found: 7
Train operators
Found: 4
Questions and Answers
What is the cheapest way to get from Siena to Isernia?
The cheapest way to get from Siena to Isernia is to bus which costs $4.46 - $5.98 and takes 5h 44m.
What is the fastest way to get from Siena to Isernia?
The fastest way to get from Siena to Isernia is to drive which takes 3h 47m and costs $65.22 - $103.26 .
Is there a direct bus between Siena and Isernia?
No, there is no direct bus from Siena to Isernia. However, there are services departing from Siena, Stazione FS and arriving at Isernia via Cassino Piazza Garibaldi. The journey, including transfers, takes approximately 5h 44m.
Is there a direct train between Siena and Isernia?
No, there is no direct train from Siena to Isernia. However, there are services departing from Siena and arriving at Isernia via Chiusi-Chianciano T. and Roma Termini. The journey, including transfers, takes approximately 7h 32m.
How far is it from Siena to Isernia?
The distance between Siena and Isernia is 391 km. The road distance is 385.1 km.
How do I travel from Siena to Isernia without a car?
The best way to get from Siena to Isernia without a car is to bus which takes 5h 44m and costs $4.46 - $5.98 .
How long does it take to get from Siena to Isernia?
It takes approximately 5h 44m to get from Siena to Isernia, including transfers.
Where do I catch the Siena to Isernia bus from?
Siena to Isernia bus services, operated by FlixBus, depart from Siena station.
Where do I catch the Siena to Isernia train from?
Siena to Isernia train services, operated by Trenitalia, depart from Siena station.
Train or bus from Siena to Isernia?
The best way to get from Siena to Isernia is to bus which takes 5h 44m and costs $4.46 - $5.98 . Alternatively, you can train, which costs $28.26 - $86.96 and takes 7h 32m.
Where does the Siena to Isernia bus arrive?
Siena to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Where does the Siena to Isernia train arrive?
Siena to Isernia train services, operated by Trenitalia, arrive at Chiusi-Chianciano T. station.
Can I drive from Siena to Isernia?
Yes, the driving distance between Siena to Isernia is 385 km. It takes approximately 3h 47m to drive from Siena to Isernia.
How do I get a train ticket from Siena to Isernia?
Book your Siena to Isernia train tickets online with Omio.
How do I get a bus ticket from Siena to Isernia?
Book your Siena to Isernia bus tickets online with Omio and FlixBus.
Where can I stay near Isernia?
There are 352+ hotels available in Isernia. Prices start at $28.95 per night.
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