How to get from Saitama to Osaka by car, truck, walk, bike

Distance between Saitama and Osaka is 398 kilometers (247 miles).
Driving distance from Saitama to Osaka is 522 kilometers (324 miles)

SaitamaOsaka
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Route Map

4 Ways from Saitama (Japan/関東 (Kanto Region)) to Osaka (Japan/近畿 (Kinki Region))

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Route instructions

1. Continue onto 中山道, 17, 463 616 m
2. Turn right onto 志木街道, 40 2.26 km
3. Turn left onto 新大宮バイパス, 17 1.43 km
4. Keep right onto 新大宮バイパス, 17 962 m
5. Keep left 603 m
6. Keep right 8.24 km
7. Keep left 294 m
8. Keep left 2.17 km
9. Turn sharp right 1.82 km
10. Keep right onto 環八通り, 311 10.62 km
11. Keep left 1.46 km
12. Turn sharp right 53 m
13. Keep right onto 東名高速道路 6.37 km
14. Keep left onto 東名高速道路, E1 84 m
15. Keep right 51.38 km
16. Keep left onto 東名高速道路(左ルート), E1 29.90 km
17. Keep left onto 新東名高速道路 256.26 km
18. Keep left 291 m
19. Keep right 29.06 km
20. Keep left 24.62 km
21. Keep left 2.96 km
22. Keep left 90.34 km
23. Keep left 266 m
24. Keep right 55 m
25. Turn slight left onto 内北浜通り 68 m
26. Turn right onto 四つ橋筋 280 m
27. Turn right onto 中之島通 475 m
28. Turn right onto 御堂筋, 25, 26, 165 55 m
29. Arrive at destination 0 m
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Questions and Answers

What is the cheapest way to get from Saitama (Japan/関東 (Kanto Region)) to Osaka (Japan/近畿 (Kinki Region))?
How do I get from Saitama (Japan/関東 (Kanto Region)) to Osaka (Japan/近畿 (Kinki Region)) the fastest?
How long does it take to get from Saitama (Japan/関東 (Kanto Region)) to Osaka (Japan/近畿 (Kinki Region))?