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How to Travel from

Chicago to Mayo Clinic

by Plane, Rideshare, Route or Car

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United States of America Chicago Mayo Clinic
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Mayo Clinic
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Cheapest
Best Offer!
Car
5 h 45 min
561 km.
from $30
Composite Route Car Only

Ten ways to Travel from Chicago to Mayo Clinic

Select an Option Below to Start Your Journey
Cheapest
By car (561 km)
5 h 45 min
561 km.
from $30
Fastest
Plane to Mayo Clinic (La Crosse Regional Airport)
Select a ticket
Other
Rideshare
5 h 45 min
561 km.
from $7.32
Bus via Chicago Bus Station
9 h 18 min
460 km.
from $107.74
Train, bus via Milwaukee, Train, bus via Milwaukee
8 h 17 min
460 km.
from $126.41
Train, Bus
9 h 57 min
460 km.
from $167.41
Bus, Plane (Fly Chicago O'Hare International Airport to La Crosse)
6 h 6 min
460 km.
from $424.47
Bus, Plane (Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport)
6 h 4 min
460 km.
from $156.85
Bus, Plane (Fly Midway International Airport to Minneapolis–Saint Paul International Airport)
5 h 47 min
460 km.
from $265.54
Bus
9 h 3 min
460 km.
from $127.78

Transport providers

Airlines

American Airlines

Website:
aa.com/
Plane from Chicago O'Hare International Airport to Rochester
Ave. Duration:
1h 21m
Frequency:
Every day
Estimated price:
$250.00–$706.52
Plane from Chicago O'Hare International Airport to La
Ave. Duration:
1h 15m
Frequency:
Every day
Estimated price:
$250.00–$1,032.61
Plane from Chicago O'Hare International Airport to Minneapolis–Saint
Ave. Duration:
1h 31m
Frequency:
Every day
Estimated price:
$108.70–$282.61

Delta

Website:
delta.com/
Plane from Chicago O'Hare International Airport to Rochester
Ave. Duration:
3h 22m
Frequency:
Every day
Estimated price:
$119.57–$402.17
Plane from Chicago O'Hare International Airport to Minneapolis–Saint
Ave. Duration:
1h 37m
Frequency:
Every day
Estimated price:
$76.09–$282.61
Plane from Midway International Airport to Minneapolis–Saint
Ave. Duration:
1h 37m
Frequency:
Every day
Estimated price:
$86.96–$315.22

United Airlines

Website:
united.com/
Plane from Chicago O'Hare International Airport to Minneapolis–Saint
Ave. Duration:
1h 34m
Frequency:
Every day
Estimated price:
$130.43–$271.74

Southwest Airlines

Website:
southwest.com/
Plane from Midway International Airport to Minneapolis–Saint
Ave. Duration:
1h 28m
Frequency:
Every day
Estimated price:
$119.57–$391.30

Sun Country Airlines

Website:
suncountry.com/
Plane from Chicago O'Hare International Airport to Minneapolis–Saint
Ave. Duration:
1h 40m
Frequency:
Saturday
Estimated price:
$59.78–$326.09

Train operators

Amtrak

Phone:
+1 800-872-7245
Website:
amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
Ave. Duration:
1h 29m
Frequency:
Every 4 hours
Estimated price:
$10.87–$76.09
Train from Chicago Union Station to St.
Ave. Duration:
7h 24m
Frequency:
3 times a day
Estimated price:
$42.39–$152.17

Bus operators

Groome Transportation

Phone:
+1 (334) 821-3399
Email:
Website:
groometransportation.com
Bus from Minneapolis / St Paul Airport to Groome
Ave. Duration:
1h 30m
Frequency:
Every 4 hours
Estimated price:
$18.48–$43.48

Flixbus USA

Phone:
+1 (855) 626-8585
Website:
flixbus.com
Bus from Chicago Bus Station to Madison
Ave. Duration:
3h 50m
Frequency:
3 times a day
Estimated price:
$15.22–$65.22

Jefferson Lines

Phone:
+1-858-800-8898
Email:
Website:
jeffersonlines.com/
Bus from Milwaukee to Rochester
Ave. Duration:
5h 40m
Frequency:
Once daily
Estimated price:
$47.83–$119.57
Bus from St. Paul to Rochester
Ave. Duration:
1h 25m
Frequency:
Once daily
Estimated price:
$22.83–$53.26
Bus from La Crosse to Rochester
Ave. Duration:
1h 50m
Frequency:
Once daily
Estimated price:
$23.91–$54.35
Bus from Madison to Rochester
Ave. Duration:
4h 20m
Frequency:
Once daily
Estimated price:
$39.13–$97.83

Vangalder Bus

Phone:
+1 608-752-5407
Email:
Website:
coachusa.com/van-galder-bus-company
Bus from W Jackson Blvd, after S Clinton St to 250
Ave. Duration:
3h 35m
Frequency:
Every 2 hours
Estimated price:
$19.57–$39.13

Questions and Answers

What is the cheapest way to get from Chicago to Mayo Clinic?

The cheapest way to get from Chicago to Mayo Clinic is to drive which costs $59.78 - $92.39 and takes 5h 42m.

What is the fastest way to get from Chicago to Mayo Clinic?

The fastest way to get from Chicago to Mayo Clinic is to fly which takes 4h 13m and costs $184.78 - $456.52 .

Is there a direct bus between Chicago and Mayo Clinic?

No, there is no direct bus from Chicago to Mayo Clinic. However, there are services departing from W Jackson Blvd, after S Clinton St and arriving at Rochester via Madison. The journey, including transfers, takes approximately 9h 3m.

How far is it from Chicago to Mayo Clinic?

The distance between Chicago and Mayo Clinic is 474 km. The road distance is 560 km.

How do I travel from Chicago to Mayo Clinic without a car?

The best way to get from Chicago to Mayo Clinic without a car is to train and bus via Milwaukee which takes 8h 17m and costs $59.78 - $195.65 .

How long does it take to get from Chicago to Mayo Clinic?

It takes approximately 4h 13m to get from Chicago to Mayo Clinic, including transfers.

Where do I catch the Chicago to Mayo Clinic bus from?

Chicago to Mayo Clinic bus services, operated by Vangalder Bus, depart from W Jackson Blvd, after S Clinton St station.

Bus or fly from Chicago to Mayo Clinic?

The best way to get from Chicago to Mayo Clinic is to fly which takes 4h 13m and costs $184.78 - $456.52 . Alternatively, you can bus, which costs $59.78 - $141.30 and takes 9h 3m.

Where does the Chicago to Mayo Clinic bus arrive?

Chicago to Mayo Clinic bus services, operated by Vangalder Bus, arrive at 250 N. Lake St - Madison UW Campus station.

Can I drive from Chicago to Mayo Clinic?

Yes, the driving distance between Chicago to Mayo Clinic is 560 km. It takes approximately 5h 42m to drive from Chicago to Mayo Clinic.

Where can I stay near Mayo Clinic?

There are 92+ hotels available in Mayo Clinic. Prices start at $50.10 per night.
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