How to Travel from
Melipilla to La Serena
by Route or Car
Schedule
Melipilla, Chile → La Serena, Chile
All
08 Jul 2026
July 2026
Mon
Tue
Wed
Thu
Fri
Sat
Sun
29
30
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August 2026
Mon
Tue
Wed
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27
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31
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September 2026
Mon
Tue
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31
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October 2026
Mon
Tue
Wed
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Sat
Sun
28
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November 2026
Mon
Tue
Wed
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26
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31
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December 2026
Mon
Tue
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Sun
30
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3
January 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
28
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31
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31
February 2027
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March 2027
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April 2027
Mon
Tue
Wed
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Fri
Sat
Sun
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31
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May 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
26
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29
30
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31
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June 2027
Mon
Tue
Wed
Thu
Fri
Sat
Sun
31
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5
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All days
09 Jul, Thu
10 Jul, Fri
11 Jul, Sat
12 Jul, Sun
13 Jul, Mon
Cheapest and Fastest Ways to Travel from Melipilla to La Serena
Composite routes from Melipilla to La Serena
Cheapest
5 h 50 min
Car
497 km.
from $27
Other
4 h 3 min
Bus, Plane
420 km.
from $106.37
7 h 17 min
420 km.
from $30.50
7 h 43 min
420 km.
from $24.43
7 h 55 min
420 km.
from $12.74
Route Navigator Melipilla - La Serena
Get all the information you need right here
Continue onto Ortúzar
Ortúzar, 50 м
50 м
Turn right onto San Miguel
San Miguel, 127 м
127 м
Turn right onto Silva Chávez
Silva Chávez, 1 km 48 м
1 km 48 м
Turn left onto Vicuña Mackenna
Vicuña Mackenna, 79 м
79 м
Turn right onto José Massaud
José Massaud, 15 km 709 м
15 km 709 м
Keep left onto Ruta G-74-F
Ruta G-74-F, 40 km 634 м
40 km 634 м
Turn sharp left onto Avenida Diego Portales
Avenida Diego Portales, 93 м
93 м
Turn right onto Avenida Bernardo O'Higgins
Avenida Bernardo O'Higgins, 1 km 595 м
1 km 595 м
Turn left onto Avenida Arturo Prat
Avenida Arturo Prat, 56 м
56 м
Turn right onto Camino a Lo Ovalle
Camino a Lo Ovalle, 1 km 953 м
1 km 953 м
Turn left
9 km 570 м
9 km 570 м
Keep right and take F-50, F-718 toward Quilpué, Villa Alemana, La Playa, Las Dichas
Quilpué, Villa Alemana, La Playa, Las Dichas, F-50, F-718, 161 м
161 м
Keep right and take F-50 toward Quilpué, Villa Alemana
Quilpué, Villa Alemana, F-50, 349 м
349 м
Turn slight right onto Ruta F-50
Ruta F-50, 24 km 493 м
24 km 493 м
Keep right
114 м
114 м
Turn slight right onto Ruta F-560
Ruta F-560, 2 km 215 м
2 km 215 м
Keep right and take 60 toward La Calera
La Calera, 60, 40 km 344 м
40 km 344 м
Keep right
171 м
171 м
Turn right onto La Feria
La Feria, 168 м
168 м
Turn left onto Avenida Beato Alberto Hurtado
Avenida Beato Alberto Hurtado, 1 km 583 м
1 km 583 м
Turn right onto Iriarte
Iriarte, 1 km 848 м
1 km 848 м
Turn right onto José Joaquín Pérez
José Joaquín Pérez, 1 km 229 м
1 km 229 м
Keep right
58 м
58 м
Turn slight right onto Manuel Rodríguez
Manuel Rodríguez, 424 м
424 м
Continue onto Manuel Rodríguez
Manuel Rodríguez, 74 м
74 м
Turn sharp left and take 5 toward Los Vilos, La Ligua
Los Vilos, La Ligua, 5, 17 km 541 м
17 km 541 м
Keep left onto Ruta 5 Norte
Ruta 5 Norte, 343 km 684 м
343 km 684 м
Keep right and drive toward La Serena
La Serena, 1 km 794 м
1 km 794 м
Keep left
13 м
13 м
Turn left onto José Ignacio Cienfuegos
José Ignacio Cienfuegos, 215 м
215 м
Turn sharp left onto Eduardo de la Barra
Eduardo de la Barra, 117 м
117 м
Arrive at destination
Transport providers
Bus operators
Found: 15
PB
Pullman Bus
Website
FC
Flixbus Chile
Website
TU
Turbus
Website
PS
Pullman San Andrés
Website
CB
Condor Bus
Website
AN
Andimar
Website
RC
Ramos Cholele
Website
EN
Expreso Norte
Website
PC
Pluss Chile
Website
CI
Ciktur
Website
BR
Buses Romani
Website
BS
Buses Serena Mar
Website
BJ
Buses Jimenez
Website
RB
Ruta Bus 78
Website
BM
Buses Melipilla Santiago
Website
Questions and Answers
What is the cheapest way to get from Melipilla to La Serena?
The cheapest way to get from Melipilla to La Serena is to bus via Quilicura which costs $10.87 - $15.22 and takes 7h 55m.
What is the fastest way to get from Melipilla to La Serena?
The fastest way to get from Melipilla to La Serena is to bus and fly which takes 4h 3m and costs $48.91 - $119.57 .
Is there a direct bus between Melipilla and La Serena?
No, there is no direct bus from Melipilla to La Serena. However, there are services departing from Terminal de Buses de Melipilla and arriving at Terminal de Buses La Serena via Terminal San Borja. The journey, including transfers, takes approximately 7h 17m.
How far is it from Melipilla to La Serena?
The distance between Melipilla and La Serena is 483 km. The road distance is 541.8 km.
How do I travel from Melipilla to La Serena without a car?
The best way to get from Melipilla to La Serena without a car is to bus which takes 7h 17m and costs $9.24 - $42.39 .
How long does it take to get from Melipilla to La Serena?
It takes approximately 4h 3m to get from Melipilla to La Serena, including transfers.
Where do I catch the Melipilla to La Serena bus from?
Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.
Where does the Melipilla to La Serena bus arrive?
Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.
Can I drive from Melipilla to La Serena?
Yes, the driving distance between Melipilla to La Serena is 542 km. It takes approximately 5h 15m to drive from Melipilla to La Serena.
Where can I stay near La Serena?
There are 1445+ hotels available in La Serena. Prices start at $1 per night.
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