How to Travel from
Melipilla to Santa Cruz
by Route or Car
Schedule
Melipilla, Chile → Santa Cruz, Chile
All
16 Jul 2026
July 2026
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September 2026
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November 2026
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January 2027
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All days
17 Jul, Fri
18 Jul, Sat
19 Jul, Sun
20 Jul, Mon
21 Jul, Tue
Cheapest and Fastest Ways to Travel from Melipilla to Santa Cruz
Composite routes from Melipilla to Santa Cruz
Cheapest
1 h 55 min
Car
125 km.
from $6
Other
4 h 10 min
106 km.
from $12.98
5 h 6 min
Bus, Train
105 km.
from $11
5 h 10 min
106 km.
from $26.09
Route Navigator Melipilla - Santa Cruz
Get all the information you need right here
Continue onto Ortúzar
Ortúzar, 2 km 467 м
2 km 467 м
Keep right
152 м
152 м
Continue onto Variante a Melipilla
Variante a Melipilla, 29 km 679 м
29 km 679 м
Keep left onto Ruta G-60
Ruta G-60, 2 km 464 м
2 km 464 м
At roundabout, take exit 3
496 м
496 м
Continue onto Ruta de la Fruta
Ruta de la Fruta, 44 km 734 м
44 km 734 м
Keep right
57 м
57 м
Turn slight right onto Ruta H-82-I
Ruta H-82-I, 18 km 12 м
18 km 12 м
Turn right onto Ruta H-82-I
Ruta H-82-I, 17 km 598 м
17 km 598 м
Turn sharp left onto Ruta H-82-I
Ruta H-82-I, 1 km 441 м
1 km 441 м
Continue onto Ruta I-340
Ruta I-340, 3 km 794 м
3 km 794 м
Turn left onto La Estampa
La Estampa, 8 km 12 м
8 km 12 м
Turn sharp left onto San Martín
San Martín, 233 м
233 м
Turn right onto Las Toscas
Las Toscas, 323 м
323 м
Turn left onto Avenida Diego Portales
Avenida Diego Portales, 7 м
7 м
Turn right onto Las Toscas
Las Toscas, 147 м
147 м
Turn right onto 21 de Mayo
21 de Mayo, 137 м
137 м
Arrive at destination
Transport providers
Questions and Answers
What is the cheapest way to get from Melipilla to Santa Cruz?
The cheapest way to get from Melipilla to Santa Cruz is to bus and train which costs $4.24 - $31.52 and takes 5h 6m.
What is the fastest way to get from Melipilla to Santa Cruz?
The fastest way to get from Melipilla to Santa Cruz is to drive which takes 1h 53m and costs $15.22 - $22.83 .
Is there a direct bus between Melipilla and Santa Cruz?
No, there is no direct bus from Melipilla to Santa Cruz. However, there are services departing from Terminal de Buses de Melipilla and arriving at Terminal de Buses Santa Cruz via PA16-Parada 2 / and Terminal Sur de Santiago. The journey, including transfers, takes approximately 4h 10m.
How far is it from Melipilla to Santa Cruz?
The distance between Melipilla and Santa Cruz is 259 km. The road distance is 126.1 km.
How do I travel from Melipilla to Santa Cruz without a car?
The best way to get from Melipilla to Santa Cruz without a car is to bus via Santiago which takes 4h 10m and costs $5.98 - $31.52 .
How long does it take to get from Melipilla to Santa Cruz?
It takes approximately 4h 10m to get from Melipilla to Santa Cruz, including transfers.
Where do I catch the Melipilla to Santa Cruz bus from?
Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.
Where does the Melipilla to Santa Cruz bus arrive?
Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.
Can I drive from Melipilla to Santa Cruz?
Yes, the driving distance between Melipilla to Santa Cruz is 126 km. It takes approximately 1h 53m to drive from Melipilla to Santa Cruz.
Where can I stay near Santa Cruz?
There are 56+ hotels available in Santa Cruz. Prices start at $75.16 per night.
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