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How to Travel from

Melipilla to Santa Cruz

by Route or Car

Melipilla
→
+0 →
Santa Cruz
Transport search to Santa Cruz
Simply select points
A and B, and we will create
a convenient route for you 👍
Chile Melipilla Santa Cruz
Melipilla
→
+0 →
Santa Cruz
Building a composite car route
Simply select points
A and B, and we will create
a convenient route for you 👍
To build a composite route, click the "Add point" button.
You can also move and delete intermediate points.
Cheapest
Best Offer!
Car
1 h 53 min
125 km.
from $6
Composite Route Car Only
Schedule

Melipilla, Chile → Santa Cruz, Chile

All
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May 2026
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17 May, Sun

Cheapest and Fastest Ways to Travel from Melipilla to Santa Cruz

Composite routes from Melipilla to Santa Cruz

Cheapest
1 h 53 min
Car
125 km.
from $6
Other
4 h 10 min
106 km.
from $12.98
5 h 6 min
Bus, Train
105 km.
from $11
5 h 10 min
106 km.
from $26.09

Transport providers

Bus operators

Pullman Bus

Phone:
+56 600 600 0018
Email:
Website:
pullmanbus.cl
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
2h 50m
Frequency:
3 times a day
Estimated price:
$12.25–$31.81
Bus from Terminal Rodoviario de San Fernando to Terminal
Ave. Duration:
50 min
Frequency:
3 times a day
Estimated price:
$20.36–$27.99

Andimar

Phone:
+56 22 683 8528
Email:
Website:
andimar.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
2h 50m
Frequency:
Hourly
Estimated price:
$4.71–$12.72
Bus from Terminal Rodoviario de San Fernando to Terminal
Ave. Duration:
1h
Frequency:
Hourly
Estimated price:
$1.08–$6.11

TranSantin

Phone:
+56 2 2479 2925
Email:
Website:
transantin.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h 20m
Frequency:
Hourly
Estimated price:
$8.27–$13.99
Bus from Terminal Rodoviario de San Fernando to Terminal
Ave. Duration:
44 min
Frequency:
Hourly
Estimated price:
$5.98–$8.91

Expreso Santa Cruz

Email:
Website:
expresosantacruz.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h
Frequency:
Hourly
Estimated price:
$6.01
Bus from Terminal Rodoviario de San Fernando to Terminal
Ave. Duration:
1h
Frequency:
Hourly

Buses Jetsur

Phone:
+56 2 2666 5505
Email:
Website:
jetsur.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h 13m
Frequency:
3 times a day
Estimated price:
$12.25

Buses Jimenez

Phone:
+56947968400
Website:
facebook.com/buses.jimenez
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h
Frequency:
Twice daily
Estimated price:
$1.65–$2.29

Ruta Bus 78

Phone:
+56 44 369 9457
Email:
Website:
rutabus78.cl/
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h 34m
Frequency:
3 times a day
Estimated price:
$8.35

Buses Melipilla Santiago

Phone:
+56 2 2832 3801
Website:
chilepasajes.cl/es/buses/buses-melipilla-santiago
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h
Frequency:
Every 15 minutes
Estimated price:
$3.19

Train operators

EFE Trenes de Chile

Phone:
+56 22 585 5000
Email:
Website:
efe.cl/
Train from Estacion Central Alameda to San
Ave. Duration:
1h 46m
Frequency:
Every 3 hours
Estimated price:
$2.29–$4.71

Questions and Answers

What is the cheapest way to get from Melipilla to Santa Cruz?

The cheapest way to get from Melipilla to Santa Cruz is to bus and train which costs $4.24 - $31.52 and takes 5h 6m.

What is the fastest way to get from Melipilla to Santa Cruz?

The fastest way to get from Melipilla to Santa Cruz is to drive which takes 1h 53m and costs $15.22 - $22.83 .

Is there a direct bus between Melipilla and Santa Cruz?

No, there is no direct bus from Melipilla to Santa Cruz. However, there are services departing from Terminal de Buses de Melipilla and arriving at Terminal de Buses Santa Cruz via PA16-Parada 2 / and Terminal Sur de Santiago. The journey, including transfers, takes approximately 4h 10m.

How far is it from Melipilla to Santa Cruz?

The distance between Melipilla and Santa Cruz is 259 km. The road distance is 126.1 km.

How do I travel from Melipilla to Santa Cruz without a car?

The best way to get from Melipilla to Santa Cruz without a car is to bus via Santiago which takes 4h 10m and costs $5.98 - $31.52 .

How long does it take to get from Melipilla to Santa Cruz?

It takes approximately 4h 10m to get from Melipilla to Santa Cruz, including transfers.

Where do I catch the Melipilla to Santa Cruz bus from?

Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.

Where does the Melipilla to Santa Cruz bus arrive?

Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.

Can I drive from Melipilla to Santa Cruz?

Yes, the driving distance between Melipilla to Santa Cruz is 126 km. It takes approximately 1h 53m to drive from Melipilla to Santa Cruz.

Where can I stay near Santa Cruz?

There are 56+ hotels available in Santa Cruz. Prices start at $75.16 per night.
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